Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.The predominant reason was early study termination by sponsor. ApoE indicates apolipoprotein E MRI, magnetic resonance imaging PET, positron emission tomography.ĪOther reasons for not meeting inclusion and exclusion criteria include inability to comply with study requirements presence of diabetes that, in the judgment of the investigator, cannot be controlled or adequately managed inability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information in accordance with national and local subject privacy regulations other unspecified reasons that, in the opinion of the investigator or sponsor, make the participant unsuitable for enrollment history of or positive test result at screening for hepatitis C virus antibody or hepatitis B virus (defined as positive for both hepatitis B surface antigen and hepatitis B core antibody) use of allowed chronic medications at doses that have not been stable for at least 4 weeks prior to screening visit 1 and screening up to day 1 or use of AD medications at doses that have not been stable for at least 8 weeks and unknown/unclear.īSome categories with fewer than 1% of patients are not displayed, including loss of capacity, pregnancy, and protocol amendment.